EXPLORING THE GENETIC FACTORS OF ALZHEIMER'S DISEASE

Abstract

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, memory loss, and behavioral changes. It is the most common form of dementia, affecting millions of individuals worldwide. While environmental and lifestyle factors contribute to the onset of AD, growing evidence suggests that genetic factors play a pivotal role in its development and progression. This article explores the genetic underpinnings of Alzheimer's disease, focusing on the identification of key genetic risk factors, including the amyloid precursor protein (APP), presenilin 1 and 2 (PS1, PS2), and apolipoprotein E (APOE). The article further discusses the implications of these genetic factors in understanding the disease mechanisms and developing potential therapies. Additionally, we explore how genetic research, including genome-wide association studies (GWAS), is contributing to the identification of new biomarkers and therapeutic targets for AD.